Handbook of Anaesthesia & Peri-operative Medicine

Pharmacokinetics -- Clinical effects -- Newer muscle relaxants -- Case scenario 1 -- Case scenario 2 -- Further reading -- Chapter 4: Analgesic drugs -- Introduction -- Paracetamol -- Mechanism of action -- Presentation -- Dose -- Pharmacokinetics -- Drug interactions -- Toxicity -- Adverse effects -- Clinical uses -- Non-steroidal anti-inflammatory drugs (NSAIDs) -- Mechanism of action -- Presentation -- Pharmacokinetics -- Drug interactions -- Adverse effects -- Other side effects -- Contraindications of NSAIDs -- Clinical uses -- Opioids -- Opioid receptors -- Mechanism of action -- Pharmacokinetics -- Clinical effects -- Central nervous system -- Respiratory system -- Cardiovascular system -- Gastrointestinal system -- Renal system -- Other effects -- Contraindications -- Side effects -- Commonly used opioids for peri-operative analgesia -- Morphine -- Fentanyl -- Pharmacodynamics -- Pharmacokinetics -- Alfentanil -- Pharmacodynamics -- Pharmacokinetics -- Metabolism -- Remifentanil -- Pharmacodynamics -- Pharmacokinetics -- Metabolism -- Side effects -- Clinical uses -- Case scenario 1 -- Case scenario 2 -- Case scenario 3 -- Further reading -- Chapter 5: Local anaesthetics -- Introduction -- Local anaesthetic mechanism of action -- Pharmacodynamics -- Structure -- Potency -- Duration of action -- Onset of action -- Vasodilation and vasoconstriction -- Cardiovascular system -- Central nervous system -- Pharmacokinetics -- Absorption -- Distribution -- Metabolism and elimination -- Commonly used local anaesthetic agents -- Amides -- Lidocaine -- Bupivacaine -- Levobupivacaine -- Ropivacaine -- Prilocaine -- Esters -- Cocaine -- Amethocaine, also known as tetracaine -- Eutectic mixture of local anaesthetic (EMLA) -- Case scenario 1 -- Case scenario 2 -- Further reading -- Chapter 6: Peri-operative monitoring -- Introduction